Higher baseline systolic blood pressure linked to cognitive decline in CKD patients

Key points in the study are:

• Participants had a mean age of 58 years with mild-to-moderate CKD and a mean eGFR of 44 Ml/min/1.73 m2.
• The median follow-up duration was 11 years.
• 13.7 % of participants developed cognitive impairment.
• Higher baseline systolic blood pressure increases the risk of cognitive impairment.
• Compared to patients with advanced CKD, the association was stronger in adults with mild-to-moderate CKD.

Seda Babroudi, MD and colleagues wrote, “In this study, we identified the relationship between blood pressure, cognitive impairment and impaired kidney function.

Researchers revealed that a higher baseline SBP is linked to a greater likelihood of cognitive impairment in those with an estimated glomerular filtration rate (eGFR) of more than 45 mL/min/1.73 m2.

Reference:

Babroudi, Seda, et al. “Blood Pressure, Incident Cognitive Impairment, and Severity of CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study.” American Journal of Kidney Diseases, vol. 82, no. 4, Elsevier BV, Oct. 2023, pp. 443-453.e1. https://doi.org/10.1053/j.ajkd.2023.03.012.