Higher Genetically Influenced Lean Muscle Mass Lowers Alzheimer's Disease Risk by 12%.

Written By : Aditi

Medically Reviewed By : Dr. Kamal Kant Kohli

Published On 2023-07-15 04:00 GMT | Update On 2023-07-15 09:40 GMT

A study published in BMJ Medicine entitled "Genetically proxied lean mass and risk of Alzheimer's disease: mendelian randomisation study" has concluded that the study's findings indicate that genetically proxied lean mass could potentially serve as a protective factor against Alzheimer's disease.

The main objective of this study was to examine whether genetically proxied lean mass is associated with Alzheimer's disease risk.

The study design was a Mendelian randomisation study.

The Setting was a UK Biobank and genome-wide association study meta-analyses of Alzheimer's disease and cognitive performance.

The data on study participants include:

UK Biobank participants included data from 450,243 individuals who had lean and fat mass measurements.
Alzheimer's disease patients and controls: Data from an independent group of 21,982 patients with Alzheimer's disease and 41,944 controls (individuals without Alzheimer's disease).
Replication sample: Data from 7,329 Alzheimer's disease patients and 252,879 controls.
Cognitive performance: 269 867 individuals taking part in a genome-wide association study.

They measured the main outcome as the Effect of genetically proxied lean mass on the risk of Alzheimer's disease and the related phenotype of cognitive performance.

The study results could be summarised as follows:

An increase in genetically proxied appendicular lean mass reduced the risk of Alzheimer's disease by 12 %.
Higher genetically proxied appendicular lean mass had an association with increased cognitive performance, and adjusting for potential mediation through genetically proxied cognitive performance did not reduce the association between appendicular lean mass and Alzheimer's disease risk.

Based on these findings, they concluded that lean mass may be a possible modifiable protective factor for Alzheimer's disease. Further investigations are warranted for mechanisms underlying this finding and the clinical and public health implications.

Further reading:

https://bmjmedicine.bmj.com/content/2/1/e000354

Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.

NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.

Aditi

Dr. Aditi Yadav is a BDS, MDS in Periodontics and Implantology. She has a clinical experience of 5 years as a laser dental surgeon. She also has a Diploma in clinical research and pharmacovigilance and is a Certified data scientist. She is currently working as a content developer in e-health services. Dr. Yadav has a keen interest in Medical Journalism and is actively involved in Medical Research writing.

Comments Policy

Our comments section is governed by our Comments Policy . By posting comments at Medical Dialogues you automatically agree with our Comments Policy , Terms And Conditions and Privacy Policy .

Higher Genetically Influenced Lean Muscle Mass Lowers Alzheimer's Disease Risk by 12%.

Similar News

Semaglutide and Tirzepatide May Lower Dementia, Stroke, and Death Risk in Diabetic Patients With Obesity: Study

Low Hemoglobin Levels Tied to Higher Risk of Cognitive Impairment in Hemodialysis Patients: Study

Greater body roundness index among diabetes patients associated with Increased stroke risk: Study

Music Therapy May Ease Distress for Dementia Patients: Study Finds

Poor sleep quality worsens vertigo in patients with benign paroxysmal positional vertigo: Study

Why Do People with ADHD Traits Experience Depression and Lower Quality of Life? Study Sheds Light

GLP-1 Receptor Agonists Promising in Managing Idiopathic Intracranial Hypertension: JAMA Study

Ambroxol Engages Target in Parkinson's Dementia but Shows No Cognitive Benefit: Study