Improved Outcomes with Tenecteplase in Stroke Beyond 4.5 Hours: Study finds
China: Tenecteplase, has emerged as an effective thrombolytic agent when given 4.5 to 24 hours after the onset of stroke, a recent study reveals. The findings were published online in The New England Journal of Medicine.
Tenecteplase given between 4.5 to 24 hours after stroke onset resulted in less disability and similar survival rates compared to regular treatment in the trial involving Chinese patients with ischemic stroke due to large-vessel occlusion, most of whom did not undergo endovascular thrombectomy.
A stroke is considered an emergency where blood flow to the brain is blocked due to blood clots, plaque deposits, embolism, or thrombus. Tenecteplase is an effective thrombolytic agent for the management of stroke within 4.5 hours of onset. However, there is limited information on how effective tenecteplase is when administered after 4.5 hours.
To fill this knowledge gap, Yunyun Xiong, From the Department of Neurology, China and colleagues conducted a study where they randomly assigned patients with blockages in the middle cerebral artery or internal carotid artery, who had viable brain tissue identified through perfusion imaging and no access to endovascular thrombectomy, to receive tenecteplase(at a dose of 0.25 mg per kilogram of body weight; maximum dose, 25 mg) or standard medical treatment 4.5 to 24 hours after the time that the patient was last known to be well (including after stroke on awakening and unwitnessed stroke).
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