Increased insulin levels in traumatic brain injury tied to DVT: Study
China: A recent study has shown that patients showing increased insulin levels in the first 14 days following severe traumatic brain injury (TBI) may be at increased risk of deep venous thrombosis (DVT).
The study published in Neurocritical Care found that elevated insulin levels during this period (14 days) may indicate insulin resistance related to platelet hyperactivity and thus raise DVT risk.
To clarify whether insulin resistance underlies the development of DVT in patients with severe traumatic brain injury, Min Zhou, University of Science and Technology of China, Hefei, People's Republic of China, and colleagues analyzed the association between plasma insulin levels and DVT in patients with severe TBI.
For this purpose, the researchers conducted a prospective observational study of 73 patients. They measured glucose, insulin, inflammatory factors, glucagon-like peptide 1 (GLP-1), and hematological profiles during the first 14 days after TBI. Tracking of ultrasonic surveillance of DVT was done.
To determine the factors that distinguished patients with and without DVT or with and without insulin therapy, A two-way analysis of variance was used. The authors separately conducted partial correlations of insulin levels with all the variables in patients with DVT or without DVT. DVT-associated factors were analyzed by multivariable logistic regression. An assessment of neurological outcomes six months after TBI was done.
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