Increased serum magnesium lowers risk of intracranial aneurysm: Study
Higher serum magnesium levels could reduce the risk of intracranial aneurysm and the associated aneurysmal subarachnoid hemorrhage, suggests a study published in the American Academy of Neurology journal.
An intracranial aneurysm is a balloon-like bulge of an artery wall in the brain. As it increases in size, it applies pressure on the surrounding structures. Following which it may remain stagnant or may even rupture in few cases. Once ruptured, it releases blood into the subarachnoid space surrounding the brain leading to subarachnoid hemorrhage. It is a debilitating condition having severe consequences. Serum magnesium concentrations have been indicated in controlling blood pressure and ensuring the optimum function of the vascular endothelium. However, whether higher serum magnesium levels increase or decrease the risk of intracranial aneurysm and the associated subarachnoid hemorrhage has never been evaluated.
A study was conducted by Larsson S and Gill D to explore the association between serum magnesium concentration and risk of intracranial aneurysm.
The researchers utilized five single-nucleotide polymorphisms linked to the serum magnesium levels from a genome-wide association study in 23,829 participants. Also, they collected genetic association estimates for intracranial aneurysms from a genome-wide association a study conducted on 79,429 people. To get the casual estimates, the inverse-variance weighted method was used for the primary analysis
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