IV tirofiban fails to improve functional outcomes during stroke thrombectomy: RESCUE BT

China: Researchers in a recent study published in the Journal of the American Medical Association (JAMA) advise against the use of intravenous tirofiban before endovascular treatment for acute ischemic stroke. 

RESCUE BT trial showed that treatment with intravenous tirofiban before endovascular therapy in patients with large vessel occlusion acute ischemic stroke undergoing endovascular thrombectomy did not result in a significant difference in disability severity at 90 days versus placebo. 

Tirofiban is a highly selective nonpeptide antagonist of glycoprotein IIb/IIIa receptor that reversibly inhibits platelet aggregation. However, it is not certain of IV tirofiban is effective in improving functional outcomes for patients with large vessel occlusion ischemic stroke undergoing endovascular thrombectomy.

Against the above background, Zhongming Qiu, MD (Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University, Chongqing, China, and colleagues aimed to assess the efficacy and adverse events of intravenous tirofiban before endovascular thrombectomy for acute ischemic stroke secondary to large vessel occlusion in an investigator-initiated, randomized, double-blind, placebo-controlled trial implemented at 55 hospitals in China.