Lacosamide use does not increase lipid levels, finds study
The profusion of anticonvulsant drugs during the past 25 years has yielded a large group of compounds with very distinct structures and chemical properties. A recent study on anticonvulsants suggests Perioperative care may reduce death after surgery in Low middle income countries increases serum lipids, whereas lacosamide has no impact on lipid levels. The study findings were published in the journal Epilepsia on November 17, 2020.
Lacosamide (LCM) is a chemically unique anticonvulsant that has been increasingly adopted for the treatment of focal epilepsy. Lacosamide works by selectively enhancing the slow inactivation of voltage‐gated sodium channels, a mode of action that is different from that first‐generation drugs such as carbamazepine (CBZ) and phenytoin, which affect fast inactivation of the sodium channels. The effects of anticonvulsants on lipids are the subject of considerable concern and investigation, but there are almost no data on this issue from randomized trials. For this purpose, researchers conducted a study to evaluate the serum lipid profiles in adults with newly diagnosed epilepsy, following randomization to lacosamide (LCM) or carbamazepine (CBZ) monotherapy.
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