Lipid Markers Can Predict Recurrent Infarcts in intracranial atherosclerotic disease
Hyperlipidemia is a strong risk factor for intracranial atherosclerotic disease (ICAD) and clinical stroke recurrence. A recent study suggests that low-density lipoprotein and triglyceride levels at the time of index stroke or transient ischemic attack can predict recurrent infarcts independent of other clinical and imaging factors. The study findings were published in the Journal of Stroke...
Hyperlipidemia is a strong risk factor for intracranial atherosclerotic disease (ICAD) and clinical stroke recurrence. A recent study suggests that low-density lipoprotein and triglyceride levels at the time of index stroke or transient ischemic attack can predict recurrent infarcts independent of other clinical and imaging factors. The study findings were published in the Journal of Stroke & Cerebrovascular Diseases on October 26, 2021.
ICAD is a common cause of ischemic stroke with a high risk of clinical stroke recurrence. Multiple mechanisms may underlie cerebral ischemia in this condition. Dr Shyam Prabhakaran and his team conducted a study to explore the effect of serum lipid levels on subclinical infarct recurrence in the Mechanisms of earlY Recurrence in Intracranial Atherosclerotic Disease (MYRIAD) study.
- Upon analysis, the researchers observed that the mean HDL-C (37.2 vs 43.9 mg/dL) was lower and TG (113.5 vs 91.3 mg/dL) was higher, while TC (199.8 vs 174.3 mg/dL) and LDL-C (124.3 vs 101.2 mg/dL) were nominally higher among those with recurrent infarcts than those without.
- After adjusting for other clinical and imaging factors, they noted that LDL-C (adj. OR 1.022) and TG (adj. OR 1.009) were predictors of recurrent infarct at 6-8 weeks.
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