Loss of Slow-Wave Sleep Linked to Increased Risk of Dementia: JAMA

Each percentage decrease in SWS per year was linked to a 27% rise in the risk of dementia. These findings remained consistent even after adjusting for variables such as age, sex, genetic factors (APOE ε4 allele), and the use of medications.

The study also noted that the loss of SWS was more pronounced in individuals with a genetic predisposition to Alzheimer's disease, as indicated by the APOE ε4 allele. This suggests that genetic factors may interact with sleep patterns, potentially influencing the development of dementia.

Crucially, these findings open up the possibility that SWS loss could be a modifiable risk factor for dementia. If future research confirms these results, interventions aimed at promoting healthy sleep patterns could play a vital role in dementia prevention.

While current treatments for dementia remain limited, this study offers a glimmer of hope by identifying a potentially modifiable risk factor. By understanding the connection between SWS, aging, and genetics, researchers are taking significant steps toward unraveling the complex mysteries of dementia and developing new strategies for prevention and treatment. 

Reference:

Himali, J. J., Baril, A.-A., Cavuoto, M. G., Yiallourou, S., Wiedner, C. D., Himali, D., DeCarli, C., Redline, S., Beiser, A. S., Seshadri, S., & Pase, M. P. (2023). Association Between Slow-Wave Sleep Loss and Incident Dementia. In JAMA Neurology. American Medical Association (AMA). https://doi.org/10.1001/jamaneurol.2023.3889