Migraine with aura associated with young-onset cryptogenic ischemic stroke in women: Study
A new study published in the journal of Stroke showed that the most common cause of young-onset cryptogenic ischemic stroke (CIS), particularly in women and individuals with high-risk patent foramen ovale (PFO), is migraine with aura.
Dropping rates of myocardial infarction and sudden cardiac death amongst young adults, which are also highly correlated with conventional risk factors, as well as the finding that the percentage of CIS has grown, lend credence to this theory. The patients without vascular risk factors and those with CIS are the main causes of the increased incidence of young-onset ischemic stroke.
Stratified by clinically relevant patent foramen ovale (PFO), which is defined by high-risk characteristics of atrial septal aneurysm or significant right-to-left shunt, this study investigates the burden and correlations of modifiable traditional, nontraditional, and female sex-specific risk variables with young-onset CIS.
This study recruited frequency-matched stroke-free controls of the same age and sex from 19 European locations, as well as consecutive patients with recent CIS, aged 18 to 49. The relationship between risk factor counts (12 traditional, 10 nontraditional, and 5 female sex-specific) and individual risk variables, stratified by PFO, was evaluated using logistic regression. Sex and age (18–39 and 40–49 years) were used to stratify the analyses, and population-attributable risk was calculated.
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