Monitoring plasma levels of DOACs can help identify risk of stroke recurrence
Germany: In a new study published in the Journal of Thrombosis and Haemostasis it has been revealed that monitoring direct oral anticoagulant (DOAC) plasma levels may aid in identifying individuals at high risk of stroke recurrence and should be explored for select subgroups, including those with a high glomerular filtration rate (GFR).
Despite the recommended use of direct oral anticoagulants, patients with atrial fibrillation have a significant risk of ischemic stroke. In clinical studies, the risk corresponds with functional DOAC plasma levels, but the usefulness of measuring them in community usage is unknown. As a result, Gabriela Siedler and colleagues carried out this investigation to evaluate the clinical consequences and prognostic usefulness of DOAC plasma level monitoring during a steady state.
Between 2016 and 2020, 397 people taking oral anticoagulants for secondary stroke prevention were enrolled in this observational clinical cohort research of patients with ischemic stroke and atrial fibrillation. During steady-state, the functional DOAC plasma levels were assessed. The key outcome indicator was early stroke recurrence within 3 months.
The key findings of this study were as follows:
Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.
NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.