NfL a new serum biomarker, may help diagnose mild cognitive decline in elderly: Study
Plasma Neurofilament light chain (NfL) is an efficient serum biomarker for prompt and early diagnosis of cognitive decline in older adults with mild cognitive impairment (MCI), suggests a study published in the Scientific Reports.
Neurofilament light chain (NfL) is a neuron-specific structural protein, that has recently been suggested as a marker of axonal injury and neurodegeneration with potential applications for both patient monitoring and for observational and interventional studies. However, research and studies about plasma NfL and cognitive decline in older people are still limited.
A study was conducted by He L et. al wherein they included 504 older adults (median age 75 years) who expressed memory complaints from the Multidomain Alzheimer's Preventive Trial (MAPT) and were classified as normal cognition (NC) or mild cognitive impairment (MCI).
Cognitive functions were measured as mini-mental state examination (MMSE) and composite cognitive score (CCS) over a 4-year period. Plasma NfL was measured at the first or the second year of the MAPT. Mixed-effects linear models were performed to evaluate cross-sectional and longitudinal associations.
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