Oral lithium-based therapy for Alzheimer's shows promise in phase 2 A trial
A phase 2A trial for its AL001 treatment for mild to moderate Alzheimer's dementia has been launched by Alzamend Neuro Inc.
The company is developing AL001 as an oral lithium-based therapy that has the potential to deliver lithium carbonate to the brain while mitigating or avoiding current toxicities associated with lithium.
The company has announced that the first patient with mild to moderate Alzheimer's disease ("Alzheimer's") has been dosed in a 12-month Phase IIA multiple ascending dose ("MAD") study for dementia related to Alzheimer's.
The MAD study is for the purpose of evaluating the safety and tolerability of AL001 under multiple-dose, steady-state conditions and determining the maximum tolerated dose in patients diagnosed with mild to moderate Alzheimer's.
AL001 is a novel lithium-delivery system; it is a lithium-salicylate-L-proline engineered ionic cocrystal under development as an oral treatment for patients with dementia related to mild, moderate, and severe cognitive impairment associated with Alzheimer's. AL001 has the potential to deliver benefits of marketed lithium carbonate while mitigating or avoiding current toxicities associated with lithium.
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