Patients who underwent TIA have increased risk of subsequent stroke in the long-term, unravels study

Of the 38 included studies, the analysis comprised 1,71,068 patients with a median age of 69 years [IQR, 65-71] and a median percentage of male patients of 57%. In the first year, there were 5.94 stroke events per 100 person-years, while in the second through fifth years, there were 1.80 occurrences per year and in the sixth through tenth years, there were 1.72 events per year. Stroke cumulative incidence was 12.5% at 5 years and 19.8% at 10 years.

Studies that employed active vs passive outcome ascertainment approaches, cohorts recruited in or after 2007, and studies done in North America and Asia as opposed to Europe had a greater incidence of stroke. Stroke rates were lower in research with an unselected patient sample than in studies that only included patients with TIA or first-ever index events. Overall, the risk of having another stroke is consistently elevated in patients who have experienced a TIA or small stroke. 

Source:

Writing Committee for the PERSIST Collaborators, Khan, F., Yogendrakumar, V., Lun, R., Ganesh, A., Barber, P. A., Lioutas, V.-A., Vinding, N. E., Algra, A., Weimar, C., Ögren, J., Edwards, J. D., Swartz, R. H., Ois, A., Giralt-Steinhauer, E., Khanevski, A. N., Leng, X., Tian, X., Leung, T. W., … Hill, M. D. (2025). Long-term risk of stroke after transient ischemic attack or minor stroke: A systematic review and meta-analysis. JAMA: The Journal of the American Medical Association. https://doi.org/10.1001/jama.2025.2033