Pre-DMT Vitamin D Levels Influence MS Disease Activity and Onset, study finds
Italy: The risk of disease activity in multiple sclerosis (MS) can be affected by vitamin D levels before disease-modifying treatment (DMT) starts, a recent study has revealed.
"Having a genetic predisposition to higher vitamin D levels is linked to a reduced risk of disease activity and is associated with a delayed onset of multiple sclerosis," Antonino Giordano, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy, and colleagues wrote in Journal of Neurology, Neurosurgery, and Psychiatry.
Multiple sclerosis is characterized by the immune system attacking the protective sheath (myelin) covering nerve fibers, disrupting communication between the brain and the rest of the body. Disease activity in MS can manifest in various forms, including relapses, progression of disability, and overall worsening of symptoms.
The role of Vitamin D (VitD) in multiple sclerosis (MS) risk is well-established, yet its specific influence on disease activity remains a topic of debate. Considering this, Dr. Giordano and colleagues aimed to evaluate whether VitD is associated with the No-Evidence of Disease Activity-3 (NEDA-3) status two years from the DMT start. They also assessed whether this association is causal or the result of confounding factors, and explored if a genetic predisposition to higher VitD levels impacts the risk of disease activity.
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