Prenatal maternal inflammation tied to ADHD diagnosis by age 10
The available preclinical and registered data indicate that maternal inflammation during pregnancy may impact early neurodevelopment in offspring. However, there is limited clinical evidence of the risk of abnormal neurodevelopment in children later in life. In the population-based COPSAC2010 mother-child cohort, a team of researchers examined the relationship between maternal inflammation levels during pregnancy and the likelihood of a child being diagnosed with ADHD, as well as the severity of ADHD symptoms in children at age 10.
A recent study published in Brain, Behavior, and Immunity has concluded that Prenatal maternal inflammation, assessed by hs-CRP, is linked to ADHD by age 10. Maternal inflammation associated with ADHD symptom load in the full cohort. This study identified inflammation as a marker crucial for future prevention during pregnancy to improve neurodevelopmental outcomes in children.
This study followed 700 mothers and their children since pregnancy week 24. The mother's hs-CRP level at week 24 was investigated about the child's neurodevelopment at age 10. The children underwent a neurodevelopment exam using K-SADS-PL and ADHD-RS. Logistic and linear regression models were used with confounder adjustment, including socioeconomic status and maternal polygenic risk of ADHD.
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