Remnant Cholesterol Key Risk Factor for Acute Ischemic Stroke: Study

Further analysis uncovered a marked association between RC and diabetes, as well as fasting glucose levels. Among diabetic patients, the incidence of AIS surged significantly with increased RC levels. Also, the RCS analysis highlighted that in diabetic patients, the risk of AIS increased continuously with RC levels above 1.15 mmol/L.

This study conclusively identifies RC as an independent risk factor for AIS by revealing a distinct non-linear association between RC levels and the risk of stroke. The findings illuminate the necessity for targeted AIS risk assessment strategies for diabetic patients who show an increased vulnerability to higher RC levels.

The researchers advocate for incorporating RC measurements into routine assessments for AIS risk stratification in populations with diabetes. This approach could lead to more personalized and effective prevention strategies by potentially reducing the incidence of AIS. Overall, this research highlights the pathogenic role of RC in AIS but also suggests that managing RC levels could be crucial in preventing strokes in diabetic individuals.

Source:

Feng, Q., Li, H., Zhang, R.-Y., Sun, L., Zhang, S.-Y., Chen, Y., Zhang, Y., Shan, B.-S., Zhao, Z., Zhou, H., & Xu, X. (2024). Elevated remnant cholesterol is a risk factor for acute ischemic stroke. In Journal of Stroke and Cerebrovascular Diseases (Vol. 33, Issue 8, p. 107773). Elsevier BV. https://doi.org/10.1016/j.jstrokecerebrovasdis.2024.107773