Researchers find new therapy for spinal cord injury

China: An article published in Experimental Biology and Medicine describes a new therapeutic strategy for treating spinal cord injury. The study, led by Drs. Hu and Lu, First Affiliated Hospital of Bengbu Medical College in Bengbu (China), reports that the small molecule P7C3 promotes recovery in an animal model of spinal cord injury.

Spinal cord injury (SCI) is a devastating neurological disorder resulting in impaired neurological function. Currently, there are no effective treatment options for patients with SCI. However, therapeutic strategies that promote the survival of neurons and oligodendrocytes may prevent long-term neurological dysfunction. P7C3 is an orally bioavailable small molecule that crosses the blood-brain barrier and promotes neuronal survival in animal models. Pre-clinical studies have confirmed P7C3's protective effects in Parkinson's disease, traumatic brain injury, peripheral nerve injury, amyotrophic lateral sclerosis, age-associated cognitive decline, and neurodegeneration-associated depression. Nonetheless, P7C3 has not been evaluated as a treatment option for SCI.