Rizatriptan Found Ineffective for Vestibular Migraine Treatment: JAMA
A new study published in the Journal of American Medical Association showed that rizatriptan did not effectively relieve vestibular migraine symptoms within 1 hour and offered limited benefit after 24 hours. These results do not support its use for treating vestibular migraine attacks.
For individuals with weaker correlations between vestibular and migraine symptoms, the ICVD included a diagnosis of probable vestibular migraine. There is no level 1 evidence to support the widespread use of migraine-recommended medications to treat vestibular migraine. The main goal of this study was to close this gap by testing the safety and effectiveness of rizatriptan for the acute treatment of vestibular migraine episodes in a double-blind, placebo-controlled RCT.
This double-blind, randomized clinical study of rizatriptan vs placebo was carried out at two tertiary neurotologic facilities between December 2014 and July 2020 (data analysis in 2021 and sensitivity analyses in 2022 and 2024). The participants were adults with vestibular migraine. Thus, to treat up to three vestibular migraine attacks per participant, each individual was randomized in a 2:1 ratio to receive either rizatriptan 10 mg or a placebo after undergoing prospective observation to confirm diagnosis and sickness activity.
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