Statin Initiation Linked to Reduced Alzheimer's Risk, Particularly in genetically susceptible elderly: Study
Alzheimer's disease is a progressive neurodegenerative disorder, and identifying interventions to reduce its risk is crucial.;
The association between statin use and Alzheimer's disease (AD) risk, especially in relation to the APOE ε4 allele, has been unclear. A recent longitudinal cohort study aimed to investigate whether statin initiation affects incident AD and cognitive decline differently depending on APOE ε4 status. This study was published in the Neurology journal by Kumar Rajan and colleagues.
Alzheimer's disease is a progressive neurodegenerative disorder, and identifying interventions to reduce its risk is crucial.Statins, commonly used to manage cholesterol levels, have been proposed as potential candidates due to their anti-inflammatory and neuroprotective properties. However, the impact of statin use on AD risk remains debated.
The study, conducted in urban communities in Chicago, involved 4,807 participants with a mean age of 72 years, including 63% female and 61% non-Hispanic Black individuals. Statin initiation and incident AD diagnoses were recorded during the study period, along with cognitive assessments. The association between statin use and AD risk was analyzed, considering APOE ε4 allele status.
The key findings of the study were:
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