Study Suggests Genetic Factors Influence Dementia-Linked Mortality
New insights into the link between dementia and mortality have emerged from a comprehensive investigation utilizing case-control and co-twin control models. Conducted by researchers using data from the Swedish Twin Registry, the study explored the interplay of genetic and environmental influences on the association between dementia and increased mortality risk. This study was published in the journal Alzheimer’s & Dementia by Jung Yun Jang and colleagues.
The study encompassed 987 twins diagnosed with dementia and 2938 age- and sex-matched controls. Results revealed that individuals with dementia exhibited a significantly greater mortality risk compared to their matched controls, with a hazard ratio (HR) of 2.02. However, the mortality risk, while still elevated, was notably lower in twins from discordant pairs—where one had dementia and the other did not—particularly in identical twins. For instance, comparing identical twins with dementia to their non-dementia co-twin controls yielded an HR of 1.48.
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