Tight BP control may lead to more mobility in new patients with paralysis

The findings of the study are published in eLife journal.

The objective of the study was that theprevious studies in rodents had showed Mean Arterial Pressure (MAP) during SCI surgery predicted long-term functional recovery, hence the present multicenter study in patients.

The study used Intra-operative monitoring records and neurological outcome data were extracted (n=118 patients).Asimilarity of network of patients was developed from a low-dimensional space embedded using a non-linear algorithm, Isomap, and ensured topological extraction using persistent homology metrics. Confirmatory analysis was conducted through regression methods.

The results of the study were

• Network analysis pointed out that time outside of an optimum MAP range (hypotension or hypertension) during surgery was associated with lower likelihood of neurological recovery at hospital discharge.

• Logistic and LASSO regression confirmed these findings, revealing an optimal MAP range of 76-[104-117] mmHg associated with neurological recovery.

Espin and team concluded that "We show that deviation from this optimal MAP range during SCI surgery predicts lower probability of neurological recovery and suggest new targets for therapeutic intervention."

Reference: https://elifesciences.org/articles/68015