Time from stroke to epilepsy onset may predict risk of drug resistance in post stroke epilepsy
Italy: A new study published in the European Journal of Neurology suggests that significant diversity in the mechanisms or pathways leading to post-stroke epilepsy (PSE), allowing patients with a varying risk of medication resistance.
Because epileptogenesis is progressive, it begs the issue of whether the latent stage contains information about the features of the eventual epilepsy. Simona Lattanzi and colleagues undertook this investigation to see if the duration between stroke and epilepsy start was associated with the likelihood of treatment resistance in individuals with post-stroke epilepsy.
Patients with epilepsy caused by a cerebral infarction or spontaneous intracerebral hemorrhage were included in the study. The lack of adequate trials of two tolerated and adequately chosen and utilized anti-seizure medication regimens to achieve prolonged seizure independence was designated as the study's result.
The key findings of this study were as follows:
1. There were 149 patients with PSE who had a median follow-up of 5 [interquartile range (IQR) 3-9] years.
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