Unveiling Iatrogenic Alzheimer's: A Potential Threat in Medical History
In a groundbreaking revelation, scientists have shed light on the possibility of iatrogenic Alzheimer's disease (AD), a form acquired through medical procedures. Alzheimer's, known for amyloid-beta (Aβ) deposition and neurofibrillary tangles, has long been considered a complex interplay of genetic and environmental factors. However, a recent study underscores the environmental acquisition of AD, prompting a reevaluation of preventive measures in medical settings.
The study results were published in the journal Nature Medicine.
The study, which builds upon previous findings on the transmission of Aβ pathology, focused on individuals who, as children, received cadaver-derived pituitary growth hormone (c-hGH) contaminated with both Creutzfeldt–Jakob disease (CJD) prions and Aβ seeds. While prior reports detailed Aβ transmission in iatrogenic Creutzfeldt–Jakob disease (iCJD) cases, the latest research delves into cases where recipients not only survived iCJD but also later developed dementia and biomarker changes consistent with AD.
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