Vasoactive intestinal polypeptide tied to migrane attacks, Finds JAMA Study
Vasoactive intestinal polypeptide (VIP) and pituitary adenylate cyclase-activating polypeptides (PACAPs) are structurally and functionally related, yet different in their migraine-inducing properties.
However, it remains unclear whether the lack of migraine induction can be attributed to the only transient vasodilatory response after a 20-minute infusion of vasoactive intestinal polypeptide. A 2-hour infusion of vasoactive intestinal polypeptide caused migraine attacks, suggesting an important role of vasoactive intestinal polypeptide in migraine pathophysiology, reports a study.
The study is recently published in the JAMA Network.
Lanfranco Pellesi and colleagues from the Danish Headache Center, Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark aimed to determine whether a 2-hour infusion of vasoactive intestinal polypeptide would provoke migraine attacks.
A randomized, double-blind, placebo-controlled, crossover study was conducted at the Danish Headache Center in Copenhagen, Denmark. Patients were eligible for inclusion if they were ages 18 to 40 years, weighed between 50 and 90 kg, had a diagnosis of migraine without aura as defined by the International Classification of Headache Disorders, and had a migraine frequency of 1 to 6 attacks per month.
Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.
NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.