Vitamin D Could Potentially Benefit Migraine Patients

In this systemic review and meta-analysis, the researchers searched PubMed, EMBASE, Web of Science, EBSCO and Cochrane library databases for randomized controlled trials (RCTs) exploring the effect of vitamin D for migraine patients. They included data from six randomized controlled trials with 301 patients.

Key findings of the study:

♦ Upon analysis, the researchers found that vitamin D supplementation could reduce

• Headache attacks per month (mean difference, −2.74)
• Headache days per month (mean difference −1.56) and
• Migraine disability assessment questionnaire scores (mean difference −5.72 compared with controls.

♦ However, they observed no obvious influence on attack duration (mean difference = −2.20) or headache severity (mean difference = −0.56).

The authors concluded, "Vitamin D supplementation provided additional benefits to treat migraine."

They further noted, " Our analysis is based on only six randomized controlled trials, and all of them have relatively small patient samples. We need more randomized controlled trials with the large patient [samples] to explore this issue"

For further information:

DOI: https://doi.org/10.1016/j.ajem.2021.07.062