Vitamin D Could Potentially Benefit Migraine Patients

Published On 2022-01-15 04:15 GMT   |   Update On 2022-01-15 04:15 GMT

As a primary headache, migraine has been established as the first leading disability cause worldwide in patients aged less than 50 years. A variety of dietary supplements have been introduced for migraine complimentary treatment. In a recent review, researchers have reassured that Vitamin D provides an additional benefit in the treatment of migraine. The study findings were published in...

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As a primary headache, migraine has been established as the first leading disability cause worldwide in patients aged less than 50 years. A variety of dietary supplements have been introduced for migraine complimentary treatment. In a recent review, researchers have reassured that Vitamin D provides an additional benefit in the treatment of migraine. The study findings were published in The American Journal of Emergency Medicine on October 13, 2021.

As an anti-inflammatory and antioxidant agent, vitamin D has become a topic of interest in recent years. Studies have shown a higher prevalence of vitamin D deficiency/insufficiency among migraineurs compared to controls. However, there is no consensus in prescribing vitamin D in clinical practice and it is not well established to use vitamin D supplementation for migraine. Therefore, Dr Chen Hu, from the Chongqing Hospital of Traditional Chinese Medicine in China, and colleagues conducted a meta-analysis to explore the efficacy of vitamin D for migraine patients.

In this systemic review and meta-analysis, the researchers searched PubMed, EMBASE, Web of Science, EBSCO and Cochrane library databases for randomized controlled trials (RCTs) exploring the effect of vitamin D for migraine patients. They included data from six randomized controlled trials with 301 patients.

Key findings of the study:

♦ Upon analysis, the researchers found that vitamin D supplementation could reduce

  • Headache attacks per month (mean difference, −2.74)
  • Headache days per month (mean difference −1.56) and
  • Migraine disability assessment questionnaire scores (mean difference −5.72 compared with controls.

♦ However, they observed no obvious influence on attack duration (mean difference = −2.20) or headache severity (mean difference = −0.56).

The authors concluded, "Vitamin D supplementation provided additional benefits to treat migraine."

They further noted, " Our analysis is based on only six randomized controlled trials, and all of them have relatively small patient samples. We need more randomized controlled trials with the large patient [samples] to explore this issue"

For further information:

DOI: https://doi.org/10.1016/j.ajem.2021.07.062


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Article Source :  The American Journal of Emergency Medicine

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