New mechanism helps bone cells regenerate in fractures
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London: Researchers from Belgium have discovered a mechanism for the better survival of implanted cells that improves in the healing of bone fractures.
The bone cells, which earlier had dim chances of survival because of not being prepared for lack of oxygen and nutrients at the fracture site, can survive better by being preconditioned to withstand the adverse environment before the implantation process, said the researchers from KU Leuven University.
"Reprogramming the bone cells obtained from patients might increase their survival rate from 30 percent to 60 percent, which will ultimately lead to better bone regeneration," said Geert Carmeliet, professor at the University.
The researchers, in the experiment conducted on mice, managed to switch on a survival mode in bone cells by inactivating the oxygen sensor in the bone cells before implantation.
The bone cells, which earlier had dim chances of survival because of not being prepared for lack of oxygen and nutrients at the fracture site, can survive better by being preconditioned to withstand the adverse environment before the implantation process, said the researchers from KU Leuven University.
"Reprogramming the bone cells obtained from patients might increase their survival rate from 30 percent to 60 percent, which will ultimately lead to better bone regeneration," said Geert Carmeliet, professor at the University.
The researchers, in the experiment conducted on mice, managed to switch on a survival mode in bone cells by inactivating the oxygen sensor in the bone cells before implantation.
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