Risk of stroke high in patients with arthritis,specially in young ; Plos One
In a recent development , researchers have highlighted that stroke risk was increased in multiple arthritis and similar between ischemic and hemorrhagic stroke; further suggesting that young patients with arthritis had the highest risk. The findings have been put forth in Plos One.
According to the Global Burden of Disease Study 2016, stroke accounts for almost 5% of all disability-adjusted life-years and 10% of all deaths worldwide, engendering substantial physical and emotional consequences for patients and their families . Thus, there is an urgent need to clearly understand stroke risk. A number of modifiable risk factors have been associated with most of the population attributable risk in stroke worldwide; these include hypertension, diabetes mellitus, obesity, hyperlipidemia, smoking, alcoholism, physical inactivity, diet, psychosocial factors, and cardiac causes. However, studies on these traditional risk factors (RF) cannot fully explain the continuous increase in stroke risk.
Inflammatory mediators such as cytokines may be the critical factor linking arthritis and stroke. Arthritis involves the increased generation of inflammatory cytokines produced in the joints. These eventually spill into the circulation, where they can cause increased production of adhesion molecules and other proinflammatory molecules. This leads to monocyte and leukocyte adhesion to the endothelial cells of the vessel wall, followed by chemotaxis of these into vessel walls, which leads to atherosclerosis, and ultimately to vascular events such as stroke .This led the research team to have a deeper look into the matter.
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