11 Formulations declared Not of Standard Quality as per data provided by states: CDSCO Drug Alert

Written By :  Dr. Divya Colin
Medically Reviewed By :  Dr. Kamal Kant Kohli
Published On 2024-09-21 12:30 GMT   |   Update On 2024-09-21 18:54 GMT
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New Delhi: In line with the 'Not of Standard Quality' data provided by states, the apex drug regulatory body, the Central Drug Standard Control Organisation (CDSCO), in its latest drug safety alert, has flagged 11 medicine batches for failing to qualify for a random sample test for August 2024.

The list of drugs declared not of standard quality includes Paziva -40 manufactured by Gnosis Pharmaceuticals, Pantomed -40 manufactured by Digital Vision, Cefixime Oral Suspension IP (Dry Syrup) manufactured by Nestor Pharmaceuticals, Moxymed CV manufactured by Alexa Pharmaceuticals, Frusemide Injection manufactured by Nestor Pharmaceuticals and others.
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Many factors contributed to the drug samples' failure in the test, such as non-compliance with the IP requirements for the particular drug, failure of the dissolution test, pH, and some assays of the drug test, among others.

In addition to the above, the alert mentioned that the Not of Standard Quality (NSQ) data was not received as per Format and in EXCEL SHEET from State Drugs Licensing Authorities of Karnataka (PDF format), Thiruvanthapuram (Excel format), and Jammu Kashmir (Excel Format) for the Month of August 2024 as per DCG(I) Circular dated 09.02.2024.

Furthermore, the alert noted that the State Drugs Licensing Authorities of Andhra Pradesh, Arunachal Pradesh, Assam, Bihar, Chhattisgarh, Goa, Gujarat, Haryana, Himachal Pradesh, Manipur, Rajasthan, Meghalaya, Mizoram, Nagaland, Odisha, Punjab, Sikkim, Tamil Nadu, Pondicherry, Telangana, Delhi, Uttarakhand, West Bengal, Andaman & Nicobar, Dadar, and Nagar Haveli; Daman and Diu, Lakshadweep have not submitted any data in respect of the Not of Standard Quality (NSQ) Alert for the Month of August, 2024 as per DCG(I) Circular dated 09.02.2024.

NOT OF STANDARD QUALITY ALERT FOR THE MONTH OF AUGUST - 2024.

B. State Laboratories

S.No

Product/Drug Name

Batch No.

Manufacturing Date

Expiry

Date

Manufactured By

NSQ Result

Reported by

CDSCO Laboratory

1.

Paziva -40

GT300234

05/23

04-25

M/s.Gnosis

Pharmaceuticals

Pvt.Ltd, Nahan Road , Village Moginand ,

Kala-Amb Dist.

Sirmour, HP- 173 030

It fails the test ‘Dissolution’

as per IP

Drugs Testing

Laboratory

Thiruvananthapura m

2.

Pantomed -40

GTEO230 C

01/24

12-25

Digital Vision 176,

Mauza ogli, Nahan

Road, Kala -Amb, Dist Sirmour - 173 030

It fails the test ‘Dissolution’

as per IP

Drugs Testing

Laboratory

Thiruvananthapura m

3.

Cefixime Oral Suspension IP (Dry Syrup)

CADA-02

09 /23

08/25

Nestor

Pharmaceuticals Ltd, 11, Western Extension Area, Faridabad -

121001

It fails the test Assay and ‘water’ as

per IP

Drugs Testing

Laboratory

Thiruvananthapura m

4.

Moxymed CV

ABT 23316

11/23

04/25

Alexa Pharmaceuticals

, Plot No. 20, Ext

HPSIDC, Indl.Area, Baddi, Solan 173 205

The content of Amoxycillin

and

Clavulanic

acid is not

with in the

limits of

schedule ‘V’ of Drugs and Cosmetics

Act & Rules as mentioned

Drugs Testing

Laboratory

Thiruvananthapura m

in the

Laboratory

protocol

5.

Frusemide

Injection IP 20 mg

FRIB-03

01/24

12/25

Nestor

Pharmaceuticals Ltd, Faridabad- 121 001

It fails the

test Sterility as per IP

Drugs Testing

Laboratory

Thiruvananthapura m

6.

Kudajarishtam

0110

01/24

Nil

Bala Herbals,

Industrial Estate,

Edakkulangara, Kollam

It fails the

tests ‘Total

Solids’ and

Specific

gravity’ as

per API.

Drugs Testing

Laboratory

Thiruvananthapura m

7.

Tab Nodosis

SMST-

24151

02/24

01/26

Steadfast Medishield

pvt.Ltd, At

khasra,No.322,

Nanhera , Anantpur, Bhgwanpur, Roorkee,

Dist. Haridwar

It fails the test Assay as

per IP

Drugs Testing

Laboratory

Thiruvananthapura m

8.

Haridrakhanda m

207/23

03/24

02/26

Bhaskara Vilasam

Vaidyasala,

Panayamuttom,

Nedumangadu,

Thiruvananthapuram - 695 561

It fails the test ‘pH’ as per

API.

Drugs Testing

Laboratory

Thiruvananthapura m

9.

Pantoprazole

Inj. BP 40 mg

D0726/24- 25

Kerala Medical

Services Corporation Ltd, Thycaud.P.O,

Thiruvananthapuram

The sample

does not

comply with

BP. It fails the test

Particulate

contaminatio n clarity and colour of

solution.

Drugs Testing

Laboratory

Thiruvananthapura m

10.

Yogaraja

Guggulu

209/21

03/22

3 yrs from mfg date

Bhaskara Vilasam

Vaidyasala,

Panayamuttom,

Nedumangadu,

Thiruvananthapuram - 695 561

It fails the test

Alcohol

Soluble

Extractive

and pH as

per API

Drugs Testing

Laboratory

Thiruvananthapura m

11.

PANCEF-OF

T442401

Jan-24

Dec-25

Aglomed Ltd. 51,

Raipur , Roorkee -

247661 . H.O : 702-A, Poonam Chambers , Dr. A.B Road , Worli , Mumbai - 400018,

India

The sample does not

comply with

respect to

the test

parameters at S.No II d

(Disintegratio n Test)

Drug Testing

Laboratory

Srinagar (J&K) vide report on Form 13 bearing No.

L/DA/2024-25/978 Dated: 07.08.2024

Also Read:CDSCO Panel Approves Pfizer's Protocol Amendment Proposal for antimicrobial drug Sisunatovir study

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