AstraZeneca Asthma drug Fasenra fails one main goal in study of chronic immune disease
UK: High-level results from the MESSINA Phase III trial showed that AstraZeneca's Fasenra (benralizumab) did not meet one of the two dual-primary endpoints. Fasenra demonstrated a statistically significant improvement in histological disease remission but not a change in dysphagia symptoms, compared to placebo, in patients with Eosinophilic esophagitis (EoE) aged 12 years or older.
Eosinophilic esophagitis is a rare, progressive, chronic inflammatory disease of the esophagus currently believed to be characterised by the abnormal presence of eosinophils, a type of white blood cell, in the inner lining of the esophagus. Patients experience difficulty with swallowing (dysphagia), pain, food getting stuck, and anxiety.
Mene Pangalos, Executive Vice President, BioPharmaceuticals R&D, AstraZeneca said: "The results from the MESSINA Phase III trial in eosinophilic esophagitis confirm that Fasenra achieved near complete depletion of tissue eosinophils, consistent with its mechanism of action, however, this did not translate into an improvement in dysphagia symptoms. We will continue to analyse the complete data set to share with the scientific community."
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