AstraZeneca, BioInvent ink pact to evaluate BI-1206 in combo with rituximab, Calquence
Sweden: BioInvent International AB, a biotech company focused on the discovery and development of novel and first-in-class immune-modulatory antibodies for cancer immunotherapy, has announced a clinical supply agreement with AstraZeneca to evaluate BioInvent's anti-FcyRIIB antibody, BI-1206, in combination with rituximab and Calquence (acalabrutinib), in a Phase 1/2a study in non-Hodgkin's lymphoma (NHL).
Under the terms of the supply agreement, AstraZeneca will provide Calquence, a selective inhibitor of Bruton's tyrosine kinase (BTK), for use in combination with BI-1206 and rituximab in the ongoing Phase 1/2a clinical study (NCT03571568) for the treatment of patients with follicular lymphoma who have progressed or are refractory to rituximab.
"Having already shown the benefits of combining BI-1206 with rituximab, we believe the addition of Calquence for a triplet combination could further improve clinical outcomes for patients with non-Hodgkin's lymphoma, including follicular lymphoma and mantle cell lymphoma, " said Dr. Martin Welschof, CEO of BioInvent. “We are extremely pleased to be entering into this supply agreement with AstraZeneca that allows us to explore a potential new, chemo-free, treatment option for these patients. "
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