AstraZeneca breast cancer drug combination gets USFDA okay
Truqap belongs to a class of drugs known as AKT inhibitors and works by targeting the AKT1 gene mutation, which is responsible for growth and proliferation of tumor.;
Cambridge: The U.S. Food and Drug Administration has approved AstraZeneca's Truqap in combination with an older drug, providing another treatment option for patients with the most common type of breast cancer.
The FDA decision allows use of the drug, chemically known as capivasertib, in combination with the British drugmaker's older cancer treatment faslodex.
The Truqap combination enters a competitive market of breast cancer treatments, which include AstraZeneca-Daiichi Sankyo's Enhertu and Gilead's Trodelvy.
FDA said Truqap can be used in adult patients with the HR-positive/HER2-negative subtype of breast cancer. The agency also allowed use of the drug in patients whose tumors had one of the three genes — PIK3CA, AKT1 or PTEN — altered.
The drug helped improve the time patients with the gene-altered tumors lived without their disease worsening by 7.3 months in a late-stage study.
Truqap belongs to a class of drugs known as AKT inhibitors and works by targeting the AKT1 gene mutation, which is responsible for growth and proliferation of tumor.
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