AstraZeneca eyes year-end filing for BP drug Baxdrostat
Written By : Ruchika Sharma
Medically Reviewed By : Dr. Kamal Kant Kohli
Published On 2025-09-01 06:56 GMT | Update On 2025-09-01 06:56 GMT
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Bengaluru: AstraZeneca plans to seek regulatory approval for its experimental blood pressure drug, baxdrostat, by the end of the year, a senior company executive stated.
Ruud Dobber, president of AstraZeneca’s biopharmaceuticals unit, confirmed the timeline ahead of a presentation of advanced clinical trial data at a medical conference on Saturday. The company is targeting potential approvals in 2026, starting with the United States and the European Union.
Baxdrostat targets blood pressure-regulating hormone aldosterone, a novel approach compared with older treatments like diuretics and ACE inhibitors, which do not address hormonal drivers.
AstraZeneca expects peak annual sales for the drug to exceed $5 billion, Reuters
Keenly watched data showed that 2mg of baxdrostat, added to standard treatment, reduced systolic blood pressure by 9.8 millimetres of mercury (mmHg) from the baseline at 12 weeks, when adjusted for placebo, in patients with hard-to-control hypertension.
"There's a huge acknowledgement that hypertension needs to be treated in a much more aggressive way," Dobber said.
High blood pressure affects over 1 billion people, according to the World Health Organization, and aggravates risk of heart attacks or strokes.
A small percentage of patients - 1.1% - taking baxdrostat developed hyperkalaemia, marked by high potassium levels in the blood. Hyperkalaemia was also observed with Mineralys' lorundrostat.
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