Biological E Typhoid Conjugate Vaccine gets WHO pre-qualification
BE's TCV is a single-dose injectable vaccine, which can be administered to children from six months of age to adults up to the age of 45 and it is formulated with vi polysaccharide conjugated to a carrier protein(CRM197).;
Hyderabad: Biological E. Limited (BE), a Hyderabad-based vaccines and pharmaceutical company, on Friday announced that its Typhoid Conjugate Vaccine (TCV) has been pre-qualified by the World Health Organisation (WHO).
With this pre-qualification, BE became one of two pre-qualified suppliers of TCV to the UN agencies.
BE's TCV is a single-dose injectable vaccine, which can be administered to children from six months of age to adults up to the age of 45 and it is formulated with Vi polysaccharide conjugated to a carrier protein (CRM197).
The Vi polysaccharide antigen used in BE's TCV is derived from C. freundii, which is a non-pathogenic source (BSL 1 organism), compared to virulent Salmonella Typhi used by other manufacturers, and the carrier protein used for conjugation is a non-toxic CRM197 protein locally developed by BE through in-house R&D effort, the company said.
Clinical studies conducted in India have shown that the safety and immunogenicity profiles of this vaccine are comparable with those of the other WHO pre-qualified TCV. BE offers this vaccine as single-dose and multi-dose vials for ease of administration.
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