Bristol Myers Squibb, Tubulis ink pact for development of next generation ADCs for cancer patients treatment
The terms of the agreement include an upfront payment of USD 22.75 million to Tubulis in addition to the potential for over USD 1 billion in development, regulatory, and commercial milestone payments plus royalty payments on resulting marketed products.;
Munich: Bristol Myers Squibb and Tubulis have announced that they have entered into a strategic license agreement to develop differentiated antibody-drug conjugates (ADCs).
Through the license agreement, Bristol Myers Squibb will gain exclusive rights to access Tubulis’ Tubutecan payloads in combination with Tubulis’ proprietary P5 conjugation platform for the development of a selected number of highly differentiated ADCs to treat solid tumors. P5 and Tubutecans facilitate the generation of ultra-stable ADCs that have the potential to actively reduce unwanted target-independent toxicities and are optimized for on-target delivery of potent topoisomerase-1 inhibitors.
The terms of the agreement include an upfront payment of $22.75 million to Tubulis in addition to the potential for over $1 billion in development, regulatory, and commercial milestone payments plus royalty payments on resulting marketed products. Following antibody target selection by Bristol Myers Squibb, Tubulis will provide the company with its linker-payload to generate a uniquely matched ADC for each antibody. Bristol Myers Squibb will assume sole responsibility for development, manufacturing, and commercialization of the resulting ADC candidates.
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