Drug safety alert: IPC flags adverse reactions linked to Cephalosporin
New Delhi: The Indian Pharmacopoeia Commission (IPC), through its recently issued drug safety alert for the month of March, has revealed that beta-lactam antimicrobials class of drugs, Cephalosporins are linked with Adverse Drug Reactions (ADRs) named Fixed Drug Eruption.
This came after preliminary analysis of Adverse Drug Reactions (ADRs) from the Pharmacovigilance Programme of India (PvPI) database.
Cephalosporins are beta-lactam antimicrobials used to manage a wide range of infections from Grampositive and Gram-negative bacteria.
Cephalosporins are bactericidal and, like other β-lactam antibiotics, disrupt the synthesis of the peptidoglycan layer forming the bacterial cell wall. The peptidoglycan layer is important for cell wall structural integrity. The final transpeptidation step in the synthesis of the peptidoglycan is facilitated by penicillin-binding proteins (PBPs). PBPs bind to the D-Ala-D-Ala at the end of muropeptides (peptidoglycan precursors) to crosslink the peptidoglycan. Beta-lactam antibiotics mimic the D-Ala-D-Ala site, thereby irreversibly inhibiting PBP crosslinking of peptidoglycan.
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