Moderna, Immatics collaborate to develop innovative oncology therapeutics

The strategic R&D collaboration between Moderna and Immatics focuses on three pillars:

• Applying Moderna's mRNA technology for in vivo expression of Immatics' next-generation, half-life extended TCR bispecifics (TCER) targeting cancer-specific HLA-presented peptides.
• Enabling the discovery and development of novel mRNA-based cancer vaccines by leveraging Moderna's deep knowledge of mRNA science and customized information from Immatics' wealth of tumor and normal tissue data included in the target discovery platform XPRESIDENT and its bioinformatics and AI platform XCUBE.
• Evaluating Immatics' IMA203 TCR-T therapy targeting PRAME in combination with Moderna's PRAME mRNA-based cancer vaccine. The collaboration contemplates conducting preclinical studies and a Phase 1 clinical trial evaluating the safety and efficacy of the combination with the objective of further enhancing IMA203 T cell responses.

"We are excited to embark on this strategic collaboration with Immatics, a pioneer in developing innovative cancer immunotherapies. This partnership presents a groundbreaking opportunity to leverage our mRNA technology alongside Immatics' TCR platform, potentially diversifying and augmenting the way we approach cancer treatment. We believe this collaboration will accelerate the development of novel oncology therapies and bring us one step closer to providing significant benefits for patients with high unmet medical needs," said Rose Loughlin, Ph.D., Moderna's Senior Vice President for Research and Early Development.

"We are thrilled to join forces with Moderna in our quest to pioneer innovative and transformative therapies to combat cancer. We believe Immatics' cancer target and TCR platforms, along with Moderna's cutting-edge mRNA technology, represent a powerful combination that has the potential to deliver meaningful benefits to cancer patients," said Toni Weinschenk, PhD, Chief Innovation Officer at Immatics. "The rapid advancement of our first 2 TCER programs into the clinic, with additional TCER compounds fueling our pre-clinical pipeline, underscores our commitment to develop innovative therapeutics. We are confident that we can explore the optimal delivery of TCER molecules through this collaboration to maximize clinical benefit in a broad patient population," added Carsten Reinhardt, MD, PhD, Chief Development Officer of Immatics.