Novartis discontinues development of GT005 in Geographic Atrophy

This decision was based on a recommendation from the independent Data Monitoring Committee (DMC) following an overall benefit risk assessment of available data from the program studies, which concluded futility criteria had been met. Importantly, no new safety signals were identified.

"While Novartis has discontinued the program studies, we are committed to ensuring patients treated with GT005 (PPY988) are provided with long term safety follow up," the company stated.

"Our disappointment in this outcome is first and foremost for the GA community. We are subsequently communicating with study investigators, Health Authorities and relevant bodies and are committed to sharing information from these early studies with the Ophthalmology and scientific communities to help inform future development of gene therapies. We sincerely thank the study participants and the investigators for their participation," the company further stated.

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