Novartis plans to invest USD 23 billion over next 5 years in US based infrastructure

With these investments, Novartis will have manufacturing capacity in the US for all its core technology platforms, including small molecules and biologics. Novartis already manufactures its most innovative, advanced therapies in the US for patients in the US and around the world. This includes cutting-edge technology platforms like gene and cell therapy and RLT manufacturing. This new investment will bring internal manufacturing of the company's siRNA technology to the US for the first time. With new manufacturing capacity, Novartis will be able to produce 100% of its key medicines end-to-end in the US, a significant increase from current levels.

"As a Swiss-based company with a significant presence in the US, these investments will enable us to fully bring our supply chain and key technology platforms into the US to support our strong US growth outlook. These investments also reflect the pro-innovation policy and regulatory environment in the US that supports our ability to find the next medical breakthroughs for patients," said Vas Narasimhan, CEO of Novartis. "We are prepared for shifts in the external environment and fully confident in our 2025 guidance, mid- to long-term sales growth outlook and 2027 core margin guidance of 40%+."

The investment includes a newly planned $1.1 billion research hub in San Diego, a state-of-the-art research facility that will provide world-class scientific infrastructure and drug discovery capabilities. The new complex, expected to open between 2028 and 2029, will serve as the epicenter of the Novartis West Coast Biomedical Research presence, complementing existing hubs in Cambridge, MA, and Basel, Switzerland.

In addition, the company will be expanding RLT manufacturing with new facilities in Florida and Texas. Novartis has established global expertise, with specialized supply chain and manufacturing capabilities across its network of RLT production facilities. To support growing demand for RLTs in the US, Novartis has already expanded production capabilities in Millburn, NJ, and a state-of-the-art facility in Indianapolis, IN, and is currently building a third US RLT manufacturing facility in Carlsbad, CA.

The US is a priority market for Novartis, and the company has taken numerous steps over its 200-year history to build its US infrastructure. Over the next 5 years, the total investment in Novartis US operations is expected to be nearly $50 billion, marking a clear demonstration of the company's focus on the US.