Panacea Biotec announces listing of EmulsiPan adjuvant in CEPI Adjuvant Library

Panacea Biotec Limited has announced the listing of EmulsiPan in the CEPI (Coalition for Epidemic Preparedness Innovations) Library of adjuvants.

EmulsiPan has been recognized for its potential in enhancing the efficacy and dose-sparing effects. EmulsiPan is an oil-in-water emulsion adjuvant and is produced by nano-emulsification of squalene along with surfactants and buffers. Squalene is a naturally occurring biodegradable and biocompatible triterpene hydrocarbon found in many plants as well as in humans. EmulsiPan is a ready-to-use sterile emulsion, supplied in a 10 mL USP Type I glass vial for research purposes. It is designed for storage at 2-8°C and maintains stability for over 2-years under recommended conditions.

On the occasion, the Chairman and Managing Director, Panacea Biotec, Dr. Rajesh Jain said, “It is with great pride that we announce the availability of EmulsiPan, a ready-to-use dosesparing adjuvant designed to enhance vaccine efficacy and support global public health initiatives. Such investments showcase our commitment to research and development investments that provide us the edge to not just meet ongoing challenges but also create a future-ready company that is prepared for every possibility and opportunity.”

The global market for adjuvants is expected to reach over $4.8 billion by 2028 with applications across vaccines and biological therapies including oncology. Oil-in-water emulsion adjuvants like EmulsiPan are used in multiple commercial vaccines like the flu vaccines.

EmulsiPan’s open access and affordability signal Panacea Biotec’s entry into commercialisation of adjuvants. The increasing prevalence of communicable diseases and the need for effective vaccines are driving the demand for oil-in-water emulsions. It is also used in animal vaccines. EmulsiPan has been utilized in several high-impact preclinical studies and collaborative research programs.

Notably, it has been employed in non-human primate (NHP) challenge studies for Sarbecoronavirus candidate vaccine development at California Institute of Technology (Caltech), and in the Betacoronavirus candidate vaccine development program in collaboration with BRIC-Translational Health Science and Technology Institute (THSTI) and funded by CEPI.

These collaborations highlight EmulsiPan as a reliable and adaptable adjuvant platform across a diverse range of vaccine development efforts.

EmulsiPan was developed in 2009 and commercialised as part of PandyFlu (Panacea Biotec’s H1N1 vaccine). 

At that time, Panacea Biotec successfully developed the adjuvant, established a cGMP manufacturing facility, developed the vaccine, including the adjuvant, on a fast-track basis to respond to the pandemic situation. EmulsiPan does not require any licensing fees - ensuring affordability and providing open access for vaccine developers.