Roche highly anticipated cancer immunotherapy fails in first late-stage trial
Tiragolumab works by selectively binding itself to TIGIT, a receptor found on immune system cells that normally serves to prevent an immune attack against healthy cells.;
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New Delhi: A highly anticipated new cancer immunotherapy by Roche failed to slow the progression of an aggressive form of lung cancer, the Swiss drug maker said on Wednesday, boding ill for a range of rival drug developers working on similar compounds.
The Skyscraper 2 trial was the first to produce results in the final stage of clinical testing in a class of drugs known as anti-TIGIT, which Roche and its U.S. unit Genentech have pioneered.
Roche said it would continue the trial programme for the drug, known as tiragolumab, against various other cancer types.
In a statement on Wednesday, the company said the drug, when combined with its established cancer drug Tecentriq and chemotherapy, failed to reduce the rate of disease progression and death when compared to a comparative group of patients on Tecentriq and chemotherapy only.
Trial participants were suffering from small cell lung cancer that had started spreading.
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