Zaynich shows over 97 percent efficacy for drug-resistant bacteria: Wockhardt

Mumbai: Wockhardt has announced that Zaynich (Zidebactam/Cefepime, WCK 5222) demonstrated over 97 percent clinical efficacy in treating seriously ill patients with infections caused by carbapenemresistant (including meropenem-resistant) Gram-negative pathogens in a ground-breaking clinical study.

The study design was unique as it encompassed a range of severe infections, including hospital-acquired bacterial pneumonia (HABP), ventilator-associated bacterial pneumonia (VABP), bloodstream infections (BSI), complicated intra-abdominal infections (cIAI), and complicated urinary tract infections (cUTI). 17% of these patients also had concurrent BSI thus further escalating the therapeutic challenge. The overall clinical efficacy of Zaynich across indications was 98% at the test-of-cure (TOC), which was 7-10 days after completion of treatment, while it was 100% for BSI, HABP/VABP & cIAI and 97.3% for cUTI.

Notably, Zaynich also demonstrated high pathogen eradication rates (microbiological cure) including for tougher-to-treat HABP/VABP (91%) and BSI patients (100%). Taking into account the results from this clinical study as well as several patients successfully treated under compassionate use in India and US, lives of more than 100 critically ill patients, infected with life-threatening XDR Gram-negative infections have been saved with administration of Zaynich.