112.5Iu r-hFSH starting dose enough for successful IVF in Amh ≥3 ng/ml: FertSert
Controlled ovarian hyperstimulation(COH) is needed in order to improve the pregnancy rate in IVF cycles. Recently, there has been an interest in using a much lower dosage of FSH for mild stimulation in IVF protocols. The purpose of this study was to assess the mild stimulation with starting dose of recombinant human FSH (r-hFSH) 112.5IU could be enough for successful IVF outcomes in patients with AMH ≥3ng/ml in IVF cycles.
Authors retrospectively reviewed 657 consecutive cycles of 594 normo-ovulatroy women(AMH ≥3ng/ml) who underwent IVF treatment over a 3-year period (2010 –2012) at their institution. Study population was divided into two groups according to r-hFSH starting dose for COH-IVF cycles.
Group A: r-hFSH(Gonal-F) starting dose 112.5IU (n=257), Group B: starting dose 150IU (n=400) in women with AMH ≥3ng/ml. Outcomes were compared the number of oocytes retrieved, total dose of r-hFSH, total r-hFSH stimulation days, clinical pregnancy and abortion rate between the two groups.
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