Azithromycin better than Erythromycin for treatment of preterm prelabour rupture of membranes: Study
Azithromycin is better than Erythromycin for the treatment of preterm prelabour rupture of membranes, according to a recent study published in the American Journal of Obstetrics and Gynecology.
This study aimed to estimate the effect of erythromycin vs azithromycin on the duration of latency and the rate of clinical chorioamnionitis in women with preterm prelabour rupture of membranes by performing a systematic review and meta-analysis of the existing literature.
Studies comparing the duration of latency and the rate of clinical chorioamnionitis between women with preterm prelabour rupture of membranes who were treated with erythromycin and those who were treated with azithromycin at the time of diagnosis were included.
Here, 2 reviewers separately ascertained studies, obtained data, and gauged study quality. The mean length of latency and the rate of clinical chorioamnionitis were compared and mean differences and odds ratios with 95% confidence intervals were estimated.
Results of the study are:
A total of 5 studies with 1289 women were identified. The mean length of latency in women with preterm prelabour rupture of membranes was similar between individuals treated with erythromycin and those treated with azithromycin: 6.6 days vs 6.7 days (mean difference, 0.07 days; 95% confidence interval, −0.45 to 0.60; I2, 0%). The median point prevalence rates of clinical chorioamnionitis were 25% (95% confidence interval, 12–32) in women treated with erythromycin and 14% (95% confidence interval, 9–24) in women treated with azithromycin. The overall clinical chorioamnionitis rate in women treated with azithromycin was lower than women treated with erythromycin (pooled odds ratio, 0.53; 95% confidence interval, 0.39–0.71; I2, 0%).
Thus, the administration of azithromycin in women with preterm prelabour rupture of membranes was associated with a similar latency period but a lower rate of clinical chorioamnionitis than the administration of erythromycin.
Reference:
Erythromycin vs azithromycin for treatment of preterm prelabour rupture of membranes: a systematic review and meta-analysis by Rachel D.Seaman et al. published in the American Journal of Obstetrics and Gynecology.
https://www.sciencedirect.com/science/article/abs/pii/S0002937821029574
Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.
NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.