Bariatric Surgery Boosts Ovulation Rates in Women with PCOS and Obesity: Lancet
Researchers have found that bariatric surgery significantly improves ovulation rates in women with polycystic ovary syndrome (PCOS) and obesity, compared to traditional medical therapy and behavioral interventions. This could have profound implications for managing infertility associated with PCOS. A recent study was published in The Lancet by Suhaniya N S and colleagues.
Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility, with obesity exacerbating reproductive complications. Despite this, effective obesity management in women with PCOS remains a clinical challenge. Observational studies have suggested that bariatric surgery might improve ovulatory cycles and fertility rates. However, its efficacy compared to behavioral modifications and medical therapy has not been tested in a randomized trial until now.
In a multicenter, open-label, randomized controlled trial, 80 women aged over 18 with a BMI of 35 kg/m² or higher and a diagnosis of PCOS, according to the 2018 international guidelines, were recruited. Participants were randomly assigned to either vertical sleeve gastrectomy or behavioral interventions and medical therapy. The primary outcome was the number of biochemically confirmed ovulatory events over 52 weeks, assessed through weekly serum progesterone measurements. The study, conducted between February 2020 and February 2021, included an intention-to-treat population for the primary endpoint and a per-protocol population for safety analyses.
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