Blood pressure and lipid profiles favorable in children born after ART with frozen embryo transfer; Study
More than 10 million children have been born after the use of assisted reproductive technology (ART). Especially the use of frozen, and later on thawed, embryos has been increasing steadily during the last decade. The health of the children born after ART is of utmost interest to the parents and to society. Studies have shown that children born after the use of frozen/thawed embryos are born with a higher birthweight compared with children conceived naturally or after the use of fresh embryos. However, the potential long-term implications of this elevated birthweight remain insufficiently explored.
This study by Asserhøj et al was part of the cohort study ‘Health in Childhood following Assisted Reproductive Technology’ (HiCART), which included 606 singletons (292 boys) born between December 2009 and December 2013: 200 children were conceived after FET; 203 children were conceived after fresh-ET; and 203 children were conceived naturally and matched for birth year and sex. The study period lasted from January 2019 to September 2021. The included children were 7–10 years of age at examination and underwent a clinical examination with anthropometric measurements, pubertal staging, and BP measurement. Additionally, a fasting blood sample was collected and analysed for cholesterol, low-density lipoproteins (LDL), high-density lipoproteins (HDL), and triglycerides. Systolic and diastolic BP were converted to standard deviation scores (SDS) using an appropriate reference and accounting for height (SDS) of the child. The three study groups were compared pairwise using a univariate linear regression model. Mean differences were adjusted for confounders using multiple linear regression analyses.
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