Chronic hypoparathyroidism during pregnancy tied to preterm birth, blood transfusions and congenital anomalies

Key results of the study are:

• Two hundred four pregnant women had chronic hypoparathyroidism, and 9,096,584 pregnancies were without chronic hypoparathyroidism.
• Comparisons were made between patients in the hypoparathyroidism group and those without hypoparathyroidism; following adjustments for age, insurance plan type, obesity, chronic hypertension, thyroid disease, pregestational diabetes mellitus, and previous caesarean section, researchers reported increased preterm birth rate, <37 weeks and blood transfusion recorded as 19.1% vs. 7.2% 4.9% vs. 1.0%.
• The aOR was 2.49 and 4.07, respectively.
• There were higher rates of congenital anomalies in Neonates to mothers with chronic hypoparathyroidism recorded as 4.4% vs 0.4% and aOR of 6.50 with comparable rates of small-for-gestational-age neonates and intrauterine foetal death.

They noted, “This is the largest study of chronic hypoparathyroidism in pregnancy to date.”

The team found elevated risk in rates of preterm birth, blood transfusions and congenital anomalies in chronic hypoparathyroidism, thereby implicating the importance of identifying chronic hypoparathyroidism as a risk factor for Pregnancy and neonatal complications.

They highlighted that there needs to be more studies to find out if maintaining calcium in the target range mitigates these risks.

Further reading:

https://pubmed.ncbi.nlm.nih.gov/37694589/