Ciprofol as effective as propofol among patients undergoing gynaecological surgery: study

Ciprofol is a recently developed, short-acting γ-aminobutyric acid receptor agonist sedative that is more potent than propofol. Still, there have been few clinical studies of this agent to date. Here, we sought to examine the safety and efficacy of ciprofol use for the induction of general anaesthesia in individuals undergoing gynaecological surgery.

Women between the ages of 18 and 60 years (ASA physical status 1 or 2) who were scheduled to undergo elective gynaecological surgery under general anaesthesia were randomly assigned to two equally sized groups in which anaesthesia induction was performed using either ciprofol or propofol. General anaesthesia induction success rates were the primary outcome for this study, while secondary outcomes included changes in BIS during the 10 min following the first administration of the study drug, the duration of successful induction, and adverse event incidence.

The results of the study are:

• A total of 120 women were included in the study.
• A 100% rate of successful induction was achieved in both the ciprofol and propofol groups, with no significant differences between these groups with respect to the duration of successful induction, the time to the disappearance of the eyelash reflex or tracheal intubation
• Adverse event rates, including intubation responses, were significantly lower in the ciprofol group as compared to the propofol group
• Ciprofol was associated with reduced injection pain relative to propofol

Thus, Ciprofol exhibits comparable efficacy to that of propofol when used for the induction of general anaesthesia in individuals undergoing gynaecological surgery and is associated with fewer adverse events.

Reference:

Chen, Bz., Yin, Xy., Jiang, Lh. et al. The efficacy and safety of ciprofol use for the induction of general anaesthesia in patients undergoing gynaecological surgery: a prospective randomized controlled study. BMC Anesthesiol 22, 245 (2022). https://doi.org/10.1186/s12871-022-01782-7

Keywords:

Ciprofol, effective, propofol, patients, undergoing, gynaecological, surgery, BMC Anesthesiology, Ben-zhen Chen, Xin-yu Yin, Li-hua Jiang, Jin-hui Liu, Yan-yan Shi & Bi-ying Yuan