Delayed cord clamping significantly reduces mortality before discharge compared to immediate cord clamping.
Delayed clamping of the umbilical cord may affect health outcomes by allowing blood flow between the placenta, umbilical cord, and baby to continue.
In their recent study, Anna Lene Seidler, PhD and colleagues concluded that deferred cord clamping, reduces death before discharge in preterm infants when compared with immediate cord clamping. This study is published in the Lancet.
Umbilical cord clamping strategies at preterm birth potentially affect essential health outcomes. This study compared the effectiveness of deferred and immediate cord clamping and umbilical cord milking at preterm birth in reducing neonatal mortality and morbidity.
Researchers searched medical databases and RCTs comparing deferred and immediate cord clamping and cord milking for preterm births, excluding quasi-randomized or cluster-randomized trials. They invited authors of eligible studies to join the collaboration and share individual participant data. They checked data and assessed bias risk. Death before hospital discharge was the primary outcome measured. They performed intention-to-treat one-stage individual participant data meta-analyses accounting for heterogeneity to examine treatment effects overall and in prespecified subgroup analyses.
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