Dequalinium Chloride Matches Metronidazole in Efficacy for Treating Bacterial Vaginosis: JAMA
Researchers have found that dequalinium chloride, a broad-spectrum antiseptic, is as effective as oral metronidazole for treating bacterial vaginosis (BV) with better tolerability and fewer adverse events. This phase 4, multicenter, triple-blind, double-dummy, noninferiority randomized clinical trial suggests that dequalinium chloride could be a promising non antibiotic treatment option for BV. This study was published in the journal JAMA Network Open by Raba G. and colleagues.
Bacterial vaginosis is a common cause of vaginal infection, with metronidazole and clindamycin being the first-line treatments. Due to rising concerns about antibiotic resistance, the need for effective non antibiotic treatments is growing. Dequalinium chloride, a broad-spectrum antiseptic, has been examined to determine if it is noninferior to oral metronidazole for treating BV.
The trial, conducted from July 29, 2021, to August 25, 2022, included 147 premenopausal women aged 18 years or older diagnosed with BV from 11 gynecologic practices and one hospital in Poland, Slovakia, and the Czech Republic. Participants were randomized to receive either dequalinium chloride vaginal tablets (10 mg once daily for six days) or oral metronidazole (500 mg twice daily for seven days). Double-dummy medication kits contained both vaginal and oral tablets with either placebo or active medication.
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